Benzocaine Synthesis

Introduction: Naturally occu work party local anaesthetic agents yield been used for all over a century to tire or alleviate the wound involved with medical procedures. Specifically, the raise of coca leaves was the first to be used. Its active ingredient, cocaine, was an effective anesthetic, yet its addictive t demiseencies caused it to be decrepit as an anesthetic and outlawed as a drug. With their greater effectiveness and rock-bottom side effects, synthetic anesthetics have fol first-class honours degree into common use. substantive to the effectiveness of many of these anesthetics is the aromatic ring at nonpareil end and possibly a standby or ordinal amine at the other end of the molecule, seperated by a one- to four-unit hydrocarbon chain. In this experiment, we will synthesize benzocaine, one of the simpler local anesthetics, from para-amino benzoic acid and ethanol in the bearing of conc. sulfuric acid. benzocaine is an odorless, white, rhombohedric crystal with low water solubility. It is peeled to light image and to temperatures above 30° C. As a drug, it has a low potency and low systemic toxicity. It is as well as a possible sulfonamide antagonist. Experimental: 1.20 g of p-amino benzoic acid and 12.0 mL of ethanol were added to a round-bottom flask with a magnetic stirbar. The classification was left to stir until the pissed dissolved.

1.0 mL of conc. sulfuric acid was slowly added and the miscellany was allowed to genly tire out under reflux for about 75 minutes. After reaction, the mixture was allowed to cool and was t ransferred to a beaker containing 30 mL of! water. 10% sodium carbonate solution was added until gas was no longer evolved and the pH was around 8. The benzocaine was collected using vacuum filtration and was rinsed with water. The increment was allowed to air dry overnight. An infared spectrum in NUJOL was obtained, and the NMR spectrum in CDCl3 was run. get to MW mass (g) vol (mL) d (g/mL) m. p. (° C) mol p-amino benzoic acid 137.14 1.2 - 1.374 188 -189...If you neediness to abbreviate a full essay, order it on our website: OrderCustomPaper.com

If you want to get a full essay, visit our page: write my paper